Two migraine-preventing drugs are now available. The latest, Ajovy, just came on the market in September. Anything that reduces migraine days is a valuable addition to the migraine toolkit. But is $500+/month Ajovy any more effective than far less-costly preventatives already available? We compare actual study results. We also explain how to avoid Medication Overuse and how to keep GERD from triggering migraines.

Keep up with us on Facebook for the latest news, research and helpful tips: Petadolex® and Dolovent™. And, as always, let us know any topics you'd like us to explore in upcoming newsletters!

Tina Sanders

Linpharma Customer Education



How Effective is the New Migraine Drug Ajovy?

Ajovy is the second, much-anticipated anti-CGRP drug approved by the FDA specifically for migraine prevention. Like the first FDA-approved drug, Aimovig, Ajovy is available as an injection and it costs over $500 a month. That's a steep price, but if the drug can give you more migraine-free days it could be well worth the cost. But how many more migraine-free days can users actually expect?

Ajovy patients reported a 23% reduction in migraines. Patients averaged 20 migraine days per month at the start of the study, and 15.5 days at the end. That's still a lot of migraine days, but it's 4.5 fewer per month. Any migraine-free day is an improvement, but is a 23% improvement the best you can do?

Let's compare results of natural alternatives studied in similarly conducted placebo-controlled clinical trials:






% reduction in migraine


Lipton, 2004

Gaul, 2015

Diener, 2005

Of all patients who saw a reduction in their migraines, how many experienced at least a 50% improvement? With Ajovy, 41%. With Petadolex, 68%.  

Bottom line: Ajovy seems like an excellent choice for chronic migraine sufferers when other strategies haven’t worked. But before committing to monthly injections costing over $500 each, it makes sense to see if a natural alternative might work even better for you than this new drug—especially if you’re experiencing fewer than 20 migraine days a month. 

Here is the physician prescribing information for the drug: Check out the facts on Ajovy yourself

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Good news: Research shows 75% of MOH sufferers were able to self-detoxify. When they did, their chronic headaches became occasional headaches.

Even better news: Detoxing from MOH may also improve the responsiveness of the migraine preventatives you use. In fact, trial data shows that just using a preventative may on its own help you avoid MOH because the fewer migraines you have, the less you need medication and so the MOH cycle doesn't gear up.
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RISK ALERT: Migraines and GERD

Do you have migraines and gastroesophageal reflux disease (GERD)? Long-term use of proton pump inhibitors like Prilosec can deplete the body’s normal levels of magnesium  Deficiencies of this critical mineral are liked with migraines.  See if you’re at risk: Symptoms of magnesium deficiency

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All-in-one, clinical strength supplement for correcting Magnesium, B2 and CoQ10 deficiencies associated with neurological discomfort.
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