Almost every month, fresh research spotlights a new reason to do all you can to the frequency and intensity of migraines. In this issue, we share a study showing that the pain and unpredictability of migraines can lay the groundwork for developing Generalized Anxiety Disorder�and we offer some strategies for helping to keep that from happening. We also report on surprising research on the effectiveness of spinal manipulation for migraine. We also look at how �migraine vitamins� work.

Thank you for reaching out with your questions and comments! We look forward to hearing what topics you�d like us to cover in upcoming issues.

Thank you!

Tina Sanders

Linpharma Customer Education



Reducing Your Risk of Developing Generalized Anxiety Disorder

If you suffer migraines, you may be at risk for developing a generalized anxiety disorder. A very large study recently conducted by researchers at the University of Toronto found that migraine sufferers were more than twice as likely to suffer from Generalized Anxiety Disorder compared to people who don�t experience migraines.

What is Generalized Anxiety Disorder?

WebMD defines it as characterized by excessive, exaggerated anxiety and worry about everyday life events even when there is no obvious reason for worrying. People with this anxiety disorder are unable to calm themselves or stop feeling that something bad may happen at any moment.

Prolonged exposure to stressful or painful situations can trigger the disorder.

What role do migraines play?

The study, published in the Headache medical journal, suggests that the �unpredictable and uncontrollable nature� of migraines is a key factor. Over time, constant worry that attacks can strike at any time and cause pain so intense it�s impossible to carry on with normal life at home and at work can create chronic anxiety. In fact, even a single intensely painful migraine can trigger powerful anxiety over the chance of experiencing a similar attack in the future. This ongoing worry over migraines can expand into generalized anxiety about every aspect of daily life. When this happens, anxiety moves from ordinary worry into a disorder that needs to be addressed by a doctor and/or a therapist.

Why are male migraine sufferers at highest risk?

Among migraine sufferers in the study, men had twice the odds of developing Generalized Anxiety Disorder compared to women. The researchers speculate that this is because men were less likely to treat their migraines. This means the migraines they experience become more painful�increasing the anxiety surrounding the possibility of experiencing another attack.

How can you reduce your own risks?

It�s important to do all you can to take control over your migraines. To view our PDF offering three practical ways to do that, CLICK HERE.

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How "Migraine Vitamins" Work

Research shows that migraine sufferers often have deficiencies of certain nutrients. When these deficiencies are corrected, migraine attacks can become less frequent, shorter, and less painful. We know, for instance, that riboflavin (Vitamin B2) supplementation can be helpful. But, our readers ask, exactly how do these �migraine vitamins� work?

One theory is that migraines occur when the brain�s nerve cells don�t have the energy to support all the demands being made on them. Vitamin B2 plays an important role in boosting energy production inside the mitochondria�the �generators� that keep each cell going. By boosting nerve cells� energy production, Vitamin B2 helps the brain cope with all the demands, preventing an overload which is thought to trigger biological reactions leading to migraines.


For migraine sufferers, the amount of Vitamin B2 needed to give nerve cells this �extra charge� may be more than it�s possible to get through diet�even with a daily multivitamin. To achieve the levels that research has identified as effective, it�s important to take a high-quality supplement. A supplement like Dolovent� can be beneficial because it combines this higher level of Vitamin B2 with two other �migraine vitamins� �magnesium and CoQ10�which also address nutritional deficiencies commonly noted in migraine sufferers. As always, talk with your doctor before taking any supplements or vitamins.

Surprising Research on Spinal Manipulation

For years, there�s been controversy over whether spinal manipulation is an effective therapy for migraine. Now, it turns out that it may be effective, but not because of the chiropractic manipulation itself.

A study published in the European Journal of Neurology showed no statistical difference in the reduction of migraines among patients divided into four different groups: one receiving actual spinal manipulation, one receiving a �sham treatment� that mimicked spinal manipulation, one receiving usual care with pharmacologic management (the control group) and one receiving �medical management� which was actually a placebo.

After three months, the three test groups all showed a significant reduction in migraine days compared the control group. But surprisingly, at the one-year mark the group receiving the placebo (medical management) had returned to their baseline number of migraine days while both the spinal manipulation and sham treatment groups improved by about 40% compared with the control group.

Here�s the interesting takeaway: Dr. Richard Lipton of New York�s Montefiore Headache Center says the fact that spinal manipulation and sham manipulation worked equally well supports two conclusions: (1) the benefits of spinal manipulation come from patients� believing it works; or (2) both manipulation techniques�both involving the �laying on of hands� �work. Either way, given the 40% improvement documented by the research, Dr. Lipton says manipulation may be worth a try, especially for migraine sufferers whose treatment needs are not met by usual, evidence-based treatments.� Note that any manipulation should be done by a trained practitioner.

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