Did you know that people who have migraines are more likely to develop depression? In this issue, we look at the link - and how magnesium deficiency just might play a role. We also have a risk update for you on taking NSAIDs for migraine pain, plus a caution about autumn migraine triggers, including five "favorite" fall foods that can make you miserable.

Thank you again for reaching out to us with your comments, questions and stories about your own migration prevention successes! Please continue to let us know what topics you'd like us to cover in upcoming issues.

Tina Sanders

Linpharma Customer Education



The Link Between Migraines and Depression

In studies published in well-respected sources like the Neurology journal, researchers report a link between migraines and depression. People with pre-existing migraines seem to be at a higher risk for developing depression, and people with pre-existing depression seem to be at a higher risk for developing migraines. Interestingly, researchers don’t find a similar relationship between depression and other types of severe headaches.

Could there be a link with magnesium, too?

What causes the migraine-depression link remains unclear, but an article from Psychology Today has us looking at an intriguing idea: Could the link be a magnesium deficiency?

According to the 2011 article, �Magnesium and the Brain: The Original Chill Pill� by Emily Deans, MD, research published decades ago in The New England Journal of Medicine reported that �magnesium deficiency could cause depression, behavioral disturbances, headaches, muscle cramps, seizures, ataxia, psychosis, and irritability �all reversible with magnesium repletion.� Dean also references a 2006 article, �Rapid Recovery from Major Depression Using Magnesium Treatment,� by George and Karen Eby. The article includes numerous case studies of using magnesium supplementation to reverse symptoms of depression.

Depression vs. deficiency?

The Ebys also speculate that the incidence of depression is growing because of widespread magnesium deficiency, caused by modern diets which lack magnesium-rich foods.

Magnesium deficiency also seems to play a role in migraines. A 2015 study on behalf of the Dolovent� Study Group, for instance, showed that migraine symptoms improved when patients took the Dolovent� supplement that includes magnesium, riboflavin and CoQ10 as the main ingredients. (NOTE: to ensure scientific validity, the study was a randomized, placebo-controlled, double-blind, multicenter trial.) This recent study adds to a substantial body of research showing a link between magnesium deficiency and migraines.

So, what we have is research showing:

  • A link between migraines and depression
  • A link between migraines and magnesium deficiency
  • A link between depression and magnesium deficiency

While there isn�t enough research to draw conclusions, there is enough research for you to talk with your doctor about your magnesium levels. This is particularly important if you�re experiencing migraines plus symptoms such as insomnia, fatigue, irritability, anger and anxiety. While these may be temporary responses to stress, they could also be signals of depression that need to be addressed.

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Minimizing Fall Migraine Triggers

Is Autumn the worst time for your migraines? A recent study showed that from September through November adults reported more frequent migraine attaches during fall than any other time of the year. From an uptick in allergens (like leaf mold), to dry indoor air and the potential for developing a Vitamin D deficiency, there are certainly plenty of potential triggers this time of year.


That�s why following your migraine prevention plan becomes even more important in fall. Starting now, you may want to add an extra precaution to that plan: watching out for five favorite fall foods that can increase the risk of suffering an attack. What are these five favorites? Click here for the PDF

RISK UPDATE: Taking NSAIDs for Migraine Pain

When chronic migraine sufferers can�t afford the sleepiness or �wooziness� that can come with prescription migraine medications, many use ibuprofens or other NSAIDs (non-steroidal anti-inflammatories) to treat pain. Although they are available over the counter, NSAIDs can expose you to serious risks.

In 2015, the FDA strengthened its warnings and labeling changes were recommended for prescription NSAIDs. FDA plans to request similar updates to the current heart attack and stroke and risk information on the drug facts labels of non-aspirin NSAIDs. In the meantime, it’s important to understand the risk and, according to the FDA, that the risk may increase with longer use. Obviously, the more you can do to prevent migraines from occurring in the first place, the less you’ll need to take NSAIDS—or the risks that come with them.

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